How does an Isotope Stress Test work?
How is an Isotope Stress Test performed?
Preparing for the test?
How long does it take?
How safe is it?
What is the reliability of the test?
How quickly will I get the results?
 

			John L. Finklea MD, FACC
		Erin Ferguson Nuclear Medicine Tech

How does an Isotope Stress Test Work? An isotope stress test is also known as a nuclear, thallium, Cardiololite, Myoview or dual isotope stress test, depending upon the method used.
     During exercise, healthy coronary arteries dilate (develop a more open channel) more than an artery that has a blockage. This unequal dilation causes more blood to be delivered to heart muscle supplied by the normal artery. In contrast, narrowed arteries end up supplying reduced flow to it's area of distribution. This reduced flow causes the involved muscle to "starve" during exercise. The "starvation" may produce symptoms (like chest discomfort or inappropriate shortness of breath), and EKG abnormalities. When a "perfusion tracer" (a nuclear isotope that travels to heart muscle with blood flow) is injected intravenously, it is extracted by the heart muscle in proportion to the flow of blood.
The amount of tracer uptake helps differentiate normal muscle (which receives more of the tracer) from the reduced uptake demonstrated by muscle that is supplied by a narrowed coronary artery. In other words, areas of the heart that have adequate blood flow quickly picks up the tracer material. In contrast, muscle with reduced blood flow pick up the tracer slowly or not at all. Analysis of the images of the heart (taken by a scanning camera) can help identify the location, severity and extent of reduced blood flow to the heart. The reduced blood flow is known as ischemia (pronounced is-keem-ya).

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      The patient is brought to the exercise laboratory where the heart rate and blood pressure are recorded at rest. Sticky electrodes are attached to the chest, shoulders and hips and connected to the EKG portion of the Stress test machine. A 12-lead EKG is recorded on paper. Each lead of the EKG represents a different portion of the heart, with adjacent leads representing a single wall (see Regular Treadmill for details). The treadmill is then started at a relatively slow "warm-up" speed. The treadmill speed and it's slope or inclination are increased every three minutes according to a preprogrammed protocol. Bruce is the commonest protocol in the USA, but several other protocols are perfectly acceptable (see Regular Treadmill for details). . It is the protocol that dictates the precise speed and slope. Each three minute interval is known as a Stage (Stage 1, Stage 2, Stage 3, etc. Thus a patient completing Stage 3 has exercised for 3 x 3 = 9 minutes). The patient's blood pressure is recorded during the second minute of each Stage. However, it may be recorded more frequently if the patient's reading is outside too high or too low.

    The EKG is constantly displayed on the monitor. It is also recorded on paper at one minute intervals. The physician pays particular attention to the heart rate, blood pressure, changes in the EKG pattern, irregular heart rhythm, and the patient's appearance and symptoms. The treadmill is stopped when the patient achieves a target heart rate (this is 85% of the maximal heart rate predicted for the patient's age). However, if the patient is doing extremely well at peak exercise, the treadmill test may be continued further. The test may be stopped prior to achievement of the target heart rate if the patient develops significant chest discomfort, shortness of breath, dizziness, unsteady gait, etc., or if the EKG shows alarming changes or serious abnormal heart rhythm. It may also be stopped if the blood pressure (BP) rises or falls beyond acceptable limits.

	Marybelle Scott ,RN
		Shelia Horne, RN

    Approximately one to 1 1/2 minutes prior to termination of exercise, the perfusion tracer or isotope is injected into the intravenous "plug" that had been placed in the forearm or hand. This is followed by a "flush" injection of saline (salt water) to make sure that all of the tracer is pushed into the blood circulation. After a brief waiting phase (that allows the tracer to be taken up by the heart muscle) the patient is placed under a scanning camera.

  Two sets of isotope images are obtained. One at rest, and one following exercise. Depending upon the isotope used and the protocol for a particular laboratory, the resting images may be obtained before the stress test, or a few hours later. The scanning camera rotates around the patient's chest, stopping to take individual pictures. The patient needs to lay flat and still during the scanning period which takes approximately 11 to 20 minutes, depending upon the type of scanning camera. Patients with severe claustrophobia should notify their physician (a mild tranquilizer before the test may minimize discomfort).
The pictures or images are fed into a computer, which reconstructs them as "slices" of a three dimensional heart. These slices are presented in three views (vertical long axis or VLA, horizontal long axis or HLA and short axis or SA). It also computes the data and presents an aggregate "bull's eye" picture that compares the information to a data base of known normal cases. Areas that fall out side the expected normal range is presented as a blacked out area. In other words, your physician has an opportunity to view a three dimensional representation of your heart, examine individual "slices" and then compare the findings against those computed by the computer as "blackout plots. By comparing one wall against another, the physician can identify disease and assess its magnitude.

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  Preparing for an Isotope Stress Test: The following recommendations are "generic" for all types of cardiac stress tests:

• Do not eat or drink for three hours prior to the procedure. This reduces the likelihood of nausea that may accompany strenuous exercise after a heavy meal. Diabetics, particularly those who use insulin, will need special instructions from the physician's office.
• Specific heart medicines may need to be stopped one or two days prior to the test. Such instructions are generally provided when the test is scheduled by the doctor's office. Call if you have any questions.
• Wear comfortable clothing and shoes that are suitable for exercise.
• An explanation of the test is provided and the patient is asked to sign a consent form.
   

  	Paul B. Moore, MD, FACP, FACC
  	Jennifer Massey, RN

How long does the entire test take? A patient should allow approximately two to four hours for the entire test, including the preparation. Dual isotope and technetium stress testing takes less time than thallium. You will be allowed to leave the lab and get a light snack or lunch in cases of thallium stress testing.

How safe is an Isotope Treadmill Stress Test? The patient is exposed to a very small amount of radiation and the risk is minimal, if any. The risk of the stress portion of the test is very small and similar to what you would expect from any strenuous form of exercise (jogging in your neighborhood, running up a flight of stairs, etc.). As noted earlier, experienced medical staff is in attendance to manage rare complications like sustained abnormal heart rhythm, unrelieved chest pain or even a heart attack. In such cases, the patient is better off having the problem in the presence of experienced staff, rather than have it happen when they are exercising alone.

What is the reliability of an Isotope Stress Test? If a patient is able to achieve the target heart rate and good quality images are obtained, an isotope treadmill stress test is capable of diagnosing important disease in approximately 85% of patients with coronary artery Approximately 10% of patients may have a "false-positive" test (when the result is falsely abnormal in a patient without coronary artery disease). Technical problems can occur when a patient is markedly overweight. Women may have an abnormality in the front portion of the heart because of overlying breast tissue. Some men may demonstrate an inferior wall abnormality because of a prominent diaphragm (muscular partition that separates the chest cavity from the abdomen). Patients who have a left bundle branch block on their EKG may also have a false abnormal test.

How quickly will I get the results and what will it mean? The physician performing the stress test can give you a preliminary report about the EKG portion of your test. However, the official result from the isotope scans may take a few days to complete. The results may influence your physician's decision to change your treatment or recommend additional testing such as cardiac catheterization, or a change in your medications.

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